Innovation: The discovery, development and demonstration of biocatalysts for use in the industrial synthesis of chiral chemicals.

Last update: 29.06.2013
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Keywords: 
biotechnology
The objective of KYROBIO project is to broaden the toolbox of single enantiomer chiral chemicals that are produced by industry in Europe using biotechnological routes. The main target is applications of lyase enzymes to selectively synthesize molecules with multiple chiral centres applying enzymatic carbon-carbon and carbon-nitrogen bond formation as the key technical platforms. We will then apply synthetic biology to improve fermentation processes in order to generate better enzymes. Chiral compounds are an important class of chemicals that biocatalytic transformation has already demonstrated great potential to compete with chemocatalysts in their production with associated benefits that come from reductions in use of organic solvents, toxic metals and energy but application has been relatively limited.

KYROBIO will address the main challenges with moving forward to the next generation of added value industrial applications of white biotechnology for high value chemical synthesis. Using a supradisciplinary approach ranging from enzyme development, chemistry, molecular biology, fermentation and innovative isolation techniques the bottlenecks to applying this new technology will be overcome. It is expected that promising candidate chemicals will be commercialised within three years of completion and so scale up with economic and feasibility studies that are also key technology developments.

The consortium includes a strong presence of SMEs including SME leadership and also a large multinational company which ensures multiple routes to market for the outcomes of this project. We will also have economic and life cycle analysis coupled with significant dissemination plans to ensure wider understanding of this technology that will lead to increased acceptance and uptake. The use of this environmentally beneficial technology will help to keep the European chemicals industry at the forefront of white biotechnology and increase opportunities in economic and employment.

PROJECT GOALS:

The discovery, development and demonstration of biocatalysts for use in the industrial synthesis of chiral chemicals.
The Discovery, Development & Demonstration of Biocatalysts for use in the Industrial Synthesis of Chiral Chemical

The objective of KYROBIO project is to broaden the toolbox of single enantiomer chiral chemicals that are produced by industry in Europe using biotechnological routes. The main target is applications of lyase enzymes to selectively synthesize molecules with multiple chiral centres applying enzymatic carbon-carbon and carbon-nitrogen bond formation as the key technical platforms. We will then apply synthetic biology to improve fermentation processes in order to generate better enzymes. Chiral compounds are an important class of chemicals that biocatalytic transformation has already demonstrated great potential to compete with chemocatalysts in their production with associated benefits that come from reductions in use of organic solvents, toxic metals and energy but application has been relatively limited. KYROBIO will address the main challenges with moving forward to the
generation of added value industrial applications of white biotechnology for high value chemical synthesis.

Using a supradisciplinary approach ranging from enzyme development, chemistry, molecular biology, fermentation and innovative isolation techniques the bottlenecks to applying this new technology will be overcome. It is expected that promising candidate chemicals will be commercialised within three years of completion and so scale up with economic and feasibility studies that are also key technology developments. The consortium includes a strong presence of SMEs including SME leadership and also a large multinational company which ensures multiple routes to market for the outcomes of this project. We will also have economic and life cycle analysis coupled with significant dissemination plans to ensure wider understanding of this technology that will lead to increased acceptance and uptake.

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This innovation is the result of the project

Title: The Discovery, Development And Demonstration Of Biocatalysts For Use In The Industrial Synthesis Of Chiral Chemicals.

Acronym: 
KYROBIO

Runtime: 
01.12.2011 to 30.11.2015

Status: 
on-going project

Organisations and people involved in this eco-innovation.

Please click on an entry to view all contact details.

C-TECH INNOVATION LIMITED

(United Kingdom)

Role in project: Project Coordination

Contact person: Mr. JONES Edward

Website: http://www.ctechinnovation.com

Phone: +441513472975

Contact

ACIB GMBH

(Austria)

Contact person: Dr. DREXLER Mathias

Website: http://www.acib.at

Phone: +43-1476548036

Contact

BICT SRL

(Italy)

Contact person: Dr. VERGA Roberto

Website: http://www.bict.it

Phone: +39-03714662452

Contact

BIO-PRODICT BV

(Netherlands)

Contact person: Ms. DOBBELSTEEN Repke

Website: http://www.bio-prodict.nl

Phone: +31-653548336

Contact

BIOINFOBANK INSTITUTE

(Poland)

Contact person: Ms. LIS MARKIEWICZ Aneta

Website: http://www.bioinfo.pl

Phone: +48-618653520

Contact

CHEMISTRY INNOVATION LIMITED

(United Kingdom)

Contact person: Dr. FLETCHER Steven

Website: http://www.chemistryinnovation.co.uk

Phone: +44-1928511096

Contact

CLEA TECHNOLOGIES BV

(Netherlands)

Contact person: Mr. VAN DER LAAN Ivo

Website: http://www.cleatechnologies.com

Phone: +31-157600300

Contact

DANMARKS TEKNISKE UNIVERSITET

(Denmark)

Contact person: Mr. REICHSTEIN Karsten

Website: http://www.dtu.dk

Phone: +45-45252800

Contact

EVOCATAL GMBH

(Germany)

Contact person: Dr. EGGERT Thorsten

Website: http://www.evocatal.com

Phone: +49-21115760951

Contact

INGENZA LIMITED

(United Kingdom)

Contact person: Dr. ARCHER Ian

Website: http://www.ingenza.com

Phone: +44-1312006360

Contact

PROZOMIX LIMITED

(United Kingdom)

Contact person: Dr. LLOYD Ruth

Website: http://www.prozomix.com

Phone: +44-1434400455

Contact

RIJKSUNIVERSITEIT GRONINGEN

(Netherlands)

Contact person: Dr. POUTSMA Jan

Website: http://www.rug.nl

Phone: +31-503634142

Contact

THE UNIVERSITY OF MANCHESTER

(United Kingdom)

Contact person: Ms. FAY Liz

Website: http://www.manchester.ac.uk

Phone: +44-1612757114

Contact

UNIVERSITAET GRAZ

(Austria)

Contact person: Ms. SCHWARZL Sabine

Website: http://www.uni-graz.at

Phone: +43-3163805350

Contact

UNIVERSITAET STUTTGART

(Germany)

Contact person: Dr. NESTL Bettina

Website: http://www.uni-stuttgart.de

Phone: +49-71168564523

Contact

VTU TECHNOLOGY TECHNOLOGIE-ENTWICKLUNGSGESELLSCHAFT MBH

(Austria)

Contact person: Dr. PURKARTHOFER Thomas

Phone: +43-31640094017

Contact

X-ZYME GMBH

(Germany)

Contact person: Dr. NA'AMNIEH Shukrallah

Phone: +49-2113398946

Contact