Innovation: Development of the next generation bioreactor system

Last update: 29.06.2013
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Keywords: 
biotechnology, industrial manufacture, agricultural biotechnology, chemical engineering, natural materials, process engineering, environmental protection, chemicals, materials technology
BIONEXGEN will develop the next generation of biocatalysts to be used for eco-efficient manufacturing processes in the chemical industry. A collaboration by industrial and academic partners have identified the key technology fields of amine synthesis, polymers from renewable resources, glycoscience and wider oxidase application as four key areas where the next generation of biocatalysts that will lead to improvements in both economic and environmental performance of the chemical manufacturing industries. This project will enable industry to use renewable resources with reduced greenhouse gas production as compared to their fossil counterparts and deliver biotechnological routes with reduced energy consumption and less toxic wastes compared to conventional chemical processes.

Routes to specialised, high-value chemicals (e.g. chiral chemical compounds) normally require long chemical synthetic routes involving complex reaction steps with toxic side products and waste streams and this project will allow these methods to be replaced by clean bio-catalysis routes. To broaden the range of fine and speciality chemicals and intermediates produced by biotechnological routes, research will address: (i) design and optimisation of enzymes to be used in synthetic chemistry, (ii) the selection/development of modified microorganisms which are resistant to heat, pressure or low pH when used in the production of chemical entities and allow (iii) the integration of biotechnological steps into conventional chemical processes.

The project will develop and integrate with chemical steps the biotechnological manufacturing routes for the synthesis of fine and speciality chemicals especially amines, oligosaccharides and renewable polymer intermediates which are better in terms of eco-efficiency, economic potential, complexity and /or specificity of the synthetic pathways than those currently employed.

Dissemination strategy will enhance the impact of this work through three separate initiatives. Economic viability and eco-efficiency will be evaluated and assessed on a quantitative basis and these results will be published in the scientific literature.

Green chemistry initiatives in the BIONEXGEN project and the FP7 contributions will be presented to the wider public on a project website and through material displays at the museum in Manchester and the Big Saturday event in Manchester Science Week. An overall end of project meeting in Brussels will invite a range of political decis

PROJECT GOALS:

Developing the Next Generation of Biocatalysts for Industrial Chemical Synthesis
BIONEXGEN will develop the
generation of biocatalysts to be used for eco-efficient manufacturing processes in the chemical industry. A collaboration by industrial and academic partners have identified the key technology fields of amine synthesis, polymers from renewable resources, glycoscience and wider oxidase application as four key areas where the
generation of biocatalysts that will lead to improvements in both economic and environmental performance of the chemical manufacturing industries.

This project will enable industry to use renewable resources with reduced greenhouse gas production as compared to their fossil counterparts and deliver biotechnological routes with reduced energy consumption and less toxic wastes compared to conventional chemical processes. Routes to specialised, high-value chemicals (e.g. chiral chemical compounds) normally require long chemical synthetic routes involving complex reaction steps with toxic side products and waste streams and this project will allow these methods to be replaced by clean biocatalysis routes.

To broaden the range of fine and speciality chemicals and intermediates produced by biotechnological routes, research will address:
design and optimisation of enzymes to be used in synthetic chemistry,
the selection/development of modified microorganisms which are resistant to heat, pressure or low pH when used in the production of chemical entities and allow
the integration of biotechnological steps into conventional chemical processes.

The project will develop and integrate with chemical steps the biotechnological manufacturing routes for the synthesis of fine and speciality chemicals especially amines, oligosaccharides and renewable polymer intermediates which are better in terms of eco efficiency, economic potential, complexity and /or specificity of the synthetic pathways than those currently employed.

266025).
BIONEXGEN will develop the
generation of biocatalysts to be used for eco-efficient manufacturing processes in the chemical industry.

A collaboration of 17 leading European companies and universities has identified key enzyme classes and technologies that are being used to develop eco-efficient manufacturing processes in the chemical industry.
The consortium consists of 17 institutions from university research groups, small and medium sized companies, to BASF, the world’s leading chemical company.

Ensuring opportunity for the project team to get acquainted, BASF hosted an excellent tour of their Wine Cellar at Ludwigshafen and subsequent dinner.
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This innovation is the result of the project

Title: Developing The Next Generation Of Biocatalysts For Industrial Chemical Synthesis

Acronym: 
BIONEXGEN

Runtime: 
01.02.2011 to 31.01.2014

Status: 
completed project

Organisations and people involved in this eco-innovation.

Please click on an entry to view all contact details.

THE UNIVERSITY OF MANCHESTER

(United Kingdom)

Role in project: Project Coordination

Contact person: Ms. FAY Liz

Website: http://www.manchester.ac.uk

Phone: +44-1612757114

Contact

ACIB GMBH

(Austria)

Contact person: Ms. STUDENCKI Julia

Website: http://www.acib.at

Phone: +43-3168739305

Contact

BASF SE

(Germany)

Contact person: Prof. ROEPER Michael

Website: http://www.basf.com

Phone: +49-6216055243

Contact

CHEMISTRY INNOVATION LIMITED

(United Kingdom)

Contact person: Mr. HARASIWKA Frank

Phone: +44-1928511820

Contact

CLEA TECHNOLOGIES BV

(Netherlands)

Contact person: Mr. VAN DER LAAN Ivo

Website: http://www.cleatechnologies.com

Phone: +31-157600300

Contact

DANMARKS TEKNISKE UNIVERSITET

(Denmark)

Contact person: WOODLEY John

Contact

ENTRECHEM SL

(Spain)

Contact person: Dr. MORIS Francisco

Website: http://www.entrechem.com

Phone: +34-985259021

Contact

GALAB LABORATORIES GMBH

(Germany)

Contact person: Dr. KUBALLA Jürgen

Phone: +49-4152889410

Contact

KUNGLIGA TEKNISKA HOEGSKOLAN

(Sweden)

Contact person: Ms. AHNLÉN Pia

Website: http://www.kth.se

Phone: +46-855378435

Contact

LEIBNIZ-INSTITUT FUR PFLANZENBIOCHEMIE

(Germany)

Contact person: Mr. FRANZEN Lothar

Website: http://www.ipb-halle.de

Phone: +49-34555821600

Contact

LENTIKAT'S A.S.

(Czech Republic)

Contact person: Dr. STLOUKAL Radek

Website: http://www.lentikats.eu

Phone: +420-224362461

Contact

MIKROBIOLOGICKY USTAV - AVCR, V.V.I.

(Czech Republic)

Contact person: Mr. KREN Vladimir

Website: http://www.biomed.cas.cz/mbu

Phone: +420-296442510

Contact

RIJKSUNIVERSITEIT GRONINGEN

(Netherlands)

Contact person: Dr. POUTSMA Jan

Website: http://www.rug.nl

Phone: +31-503634142

Contact

SLOVENSKA TECHNICKA UNIVERZITA V BRATISLAVE

(Slovakia)

Contact person: Dr. REBROS Martin

Website: http://www.stuba.sk

Phone: +421-259325480

Contact

UNIVERSIDAD DE OVIEDO

(Spain)

Contact person: Dr. HÖRLEIN Anne

Website: http://www.uniovi.es

Phone: +34-985104129

Contact

UNIVERSITAET STUTTGART

(Germany)

Contact person: Prof. HAUER Bernhard

Website: http://www.uni-stuttgart.de

Phone: +49-71168563193

Contact

UNIVERSITY COLLEGE LONDON

(United Kingdom)

Contact person: Ms. BORG-CARBOTT Greta

Phone: +44-20310-83033

Contact